1. Name Of The Medicinal Product
AVANDIA 4 mg film-coated tablets
AVANDIA 8 mg film-coated tablets
2. Qualitative And Quantitative Composition
Each tablet contains rosiglitazone maleate corresponding to 4 or 8 mg of rosiglitazone.
Excipient
AVANDIA 4 mg – contains lactose (approximately 105 mg).
AVANDIA 8 mg – contains lactose (approximately 209 mg).
For a full list of excipients, see section 6.1.
3. Pharmaceutical Form
Film-coated tablet (tablet).
AVANDIA 4 mg – orange film-coated tablets debossed with “GSK” on one side and "4" on the other side.
AVANDIA 8 mg – Red-brown film-coated tablets debossed with “GSK” on one side and "8" on the other side.
4. Clinical Particulars
4.1 Therapeutic Indications
Rosiglitazone is indicated in the treatment of type 2 diabetes mellitus:
as monotherapy
– in adults (particularly overweight adults) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance
as dual oral therapy in combination with
– metformin, in adults (particularly overweight adults) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin
– a sulphonylurea, only in adults who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite monotherapy with a sulphonylurea
as triple oral therapy in combination with
– metformin and a sulphonylurea, in adults (particularly overweight adults) with insufficient glycaemic control despite dual oral therapy (see section 4.4).
4.2 Posology And Method Of Administration
Posology
Rosiglitazone treatment is usually initiated at 4 mg/day. This dose can be increased to 8 mg/day after eight weeks if greater glycaemic control is required. In patients administered rosiglitazone in combination with a sulphonylurea, an increase in rosiglitazone to 8 mg/day should be undertaken cautiously following appropriate clinical evaluation to assess the patient's risk of developing adverse reactions relating to fluid retention (see sections 4.4 and 4.8).
Rosiglitazone may be given once or twice a day (either as one daily dose, or two divided doses).
Special populations
Elderly (
No dose adjustment is required in the elderly.
Renal impairment (see section 4.4 Fluid retention and cardiac failure)
No dose adjustment is required in patients with mild and moderate renal insufficiency. Limited data are available in patients with severe renal insufficiency (creatinine clearance < 30 ml/min) and therefore rosiglitazone should be used with caution in these patients.
Hepatic impairment
Rosiglitazone must not be used in patients with hepatic impairment (see section 4.3).
Paediatric population
There are no data available on the use of rosiglitazone in children under 10 years of age. For children and adolescents aged 10 to 17 years, there are limited data on rosiglitazone as monotherapy (see sections 5.1 and 5.2). The available data do not support efficacy in the paediatric population and therefore such use is not recommended.
Method of administration
The tablets should be swallowed with water and may be taken with or without food.
To improve medicine compliance, it is suggested that patients are advised to take the tablets around the same time every day.
4.3 Contraindications
Use of rosiglitazone is contraindicated in patients with:
− known hypersensitivity to rosiglitazone or to any of the excipients
− cardiac failure or history of cardiac failure (NYHA class I to IV)
− an Acute Coronary Syndrome (unstable angina, non-ST segment elevation myocardial infarction (NSTEMI) and ST segment elevation myocardial infarction (STEMI)) (see section 4.4)
− hepatic impairment.
− diabetic ketoacidosis and diabetic pre-coma.
4.4 Special Warnings And Precautions For Use
Fluid retention and cardiac failure
Thiazolidinediones can cause fluid retention which may exacerbate or precipitate signs or symptoms of congestive heart failure. Rosiglitazone can cause dose-dependent fluid retention. The possible contribution of fluid retention to weight gain should be individually assessed as rapid and excessive weight gain has been reported very rarely as a sign of fluid retention. All patients, particularly those receiving concurrent insulin or sulphonylurea therapy, those at risk for heart failure, and those with reduced cardiac reserve, should be monitored for signs and symptoms of adverse reactions relating to fluid retention, including weight gain and heart failure. Increased monitoring of the patient is recommended if rosiglitazone is used in combination with metformin and insulin. Rosiglitazone should be discontinued if any deterioration in cardiac status occurs.
Heart failure was also reported more frequently in patients with a history of heart failure; oedema and heart failure was also reported more frequently in elderly patients and in patients with mild or moderate renal failure. Caution should be exercised in patients over 75 years because of the limited experience in this patient group. Since NSAIDs and rosiglitazone are associated with fluid retention, concomitant administration may increase the risk of oedema.
Combination with insulin
An increased incidence of cardiac failure has been observed in clinical trials when rosiglitazone is used in combination with insulin. Insulin and rosiglitazone are both associated with fluid retention, concomitant administration may increase the risk of oedema and could increase the risk of ischaemic heart disease. Insulin should only be added to established rosiglitazone therapy in exceptional cases and under close supervision.
Myocardial ischaemia
A retrospective analysis of data from 42 pooled short-term clinical studies indicated that treatment with rosiglitazone may be associated with an increased risk of myocardial ischaemic events. However, in their entirety the available data on the risk of cardiac ischaemia are inconclusive (see section 4.8). There are limited clinical trial data in patients with ischaemic heart disease and/or peripheral arterial disease. Therefore, as a precaution, the use of rosiglitazone is not recommended in these patients, particularly those with myocardial ischaemic symptoms.
Acute Coronary Syndrome (ACS)
Patients experiencing an ACS have not been studied in rosiglitazone controlled clinical trials. In view of the potential for development of heart failure in these patients, rosiglitazone should therefore not be initiated in patients having an acute coronary event and it should be discontinued during the acute phase (see section 4.3).
Monitoring of liver function
There have been rare reports of hepatocellular dysfunction during post-marketing experience (see section 4.8). There is limited experience with rosiglitazone in patients with elevated liver enzymes (ALT>2.5X upper limit of normal). Therefore, liver enzymes should be checked prior to the initiation of therapy with rosiglitazone in all patients and periodically thereafter based on clinical judgement. Therapy with rosiglitazone should not be initiated in patients with increased baseline liver enzyme levels (ALT>2.5X upper limit of normal) or with any other evidence of liver disease. If ALT levels are increased to>3X upper limit of normal during rosiglitazone therapy, liver enzyme levels should be reassessed as soon as possible. If ALT levels remain>3X the upper limit of normal, therapy should be discontinued. If any patient develops symptoms suggesting hepatic dysfunction, which may include unexplained nausea, vomiting, abdominal pain, fatigue, anorexia and/or dark urine, liver enzymes should be checked. The decision whether to continue the patient on therapy with rosiglitazone should be guided by clinical judgement pending laboratory evaluations. If jaundice is observed, drug treatment with rosiglitazone should be discontinued.
Eye disorders
Post-marketing reports of new-onset or worsening diabetic macular oedema with decreased visual acuity have been reported with thiazolidinediones, including rosiglitazone. Many of these patients reported concurrent peripheral oedema. It is unclear whether or not there is a direct association between rosiglitazone and macular oedema but prescribers should be alert to the possibility of macular oedema if patients report disturbances in visual acuity and appropriate ophthalmologic referral should be considered.
Weight gain
In clinical trials with rosiglitazone there was evidence of dose-related weight gain, which was greater when used in combination with insulin. Therefore weight should be closely monitored, given that it may be attributable to fluid retention, which may be associated with cardiac failure.
Anaemia
Rosiglitazone treatment is associated with a dose-related reduction of haemoglobin levels. In patients with low haemoglobin levels before initiating therapy, there is an increased risk of anaemia during treatment with rosiglitazone.
Hypoglycaemia
Patients receiving rosiglitazone in combination therapy with a sulphonylurea or with insulin may be at risk for dose-related hypoglycaemia. Increased monitoring of the patient and a reduction in the dose of the concomitant agent may be necessary.
Triple oral therapy
The use of rosiglitazone in triple oral therapy, in combination with metformin and a sulphonylurea, may be associated with increased risks for fluid retention and heart failure, as well as hypoglycaemia (see section 4.8). Increased monitoring of the patient is recommended and adjustment of the dose of sulphonylurea may be necessary. The decision to initiate triple oral therapy should include consideration of the alternative to switch the patient to insulin.
Bone disorders
Long-term studies show an increased incidence of bone fractures in patients, particularly female patients, taking rosiglitazone (see section 4.8). The majority of the fractures have occurred in the upper limbs and distal lower limbs. In females, this increased incidence was noted after the first year of treatment and persisted during long-term treatment. The risk of fracture should be considered in the care of patients, especially female patients, treated with rosiglitazone.
Others
Premenopausal women have received rosiglitazone during clinical studies. Although hormonal imbalance has been seen in preclinical studies (see section 5.3), no significant adverse reactions associated with menstrual disorders have been observed. As a consequence of improving insulin sensitivity, resumption of ovulation may occur in patients who are anovulatory due to insulin resistance. Patients should be aware of the risk of pregnancy and if a patient wishes to become pregnant or if pregnancy occurs the treatment should be discontinued (see section 4.6).
Rosiglitazone should be used with caution in patients with severe renal insufficiency (creatinine clearance < 30 ml/min).
Rosiglitazone should be used with caution during concomitant administration of CYP2C8 inhibitors (e.g. gemfibrozil) or inducers (e.g. rifampicin). Glycaemic control should be monitored closely. Rosiglitazone dose adjustment within the recommended posology or changes in diabetic treatment should be considered (see section 4.5).
AVANDIA tablets contain lactose and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction
In vitro studies demonstrate that rosiglitazone is predominantly metabolised by CYP2C8, with CYP2C9 as only a minor pathway.
Co-administration of rosiglitazone with gemfibrozil (an inhibitor of CYP2C8) resulted in a twofold increase in rosiglitazone plasma concentrations. Since there is a potential for an increase in the risk of dose-related adverse reactions, a decrease in rosiglitazone dose may be needed. Close monitoring of glycaemic control should be considered (see section 4.4).
Co-administration of rosiglitazone with rifampicin (an inducer of CYP2C8) resulted in a 66 % decrease in rosiglitazone plasma concentrations. It cannot be excluded that other inducers (e.g. phenytoin, carbamazepine, phenobarbital, St John's wort) may also affect rosiglitazone exposure. The rosiglitazone dose may need to be increased. Close monitoring of glycaemic control should be considered (see section 4.4).
Clinically significant interactions with CYP2C9 substrates or inhibitors are not anticipated.
Concomitant administration with the oral anti-diabetic medicinal products metformin, glibenclamide and acarbose did not result in any clinically relevant pharmacokinetic interactions with rosiglitazone. Moderate ingestion of alcohol with rosiglitazone has no effect on glycaemic control.
No clinically relevant interactions with digoxin, the CYP2C9 substrate warfarin, the CYP3A4 substrates nifedipine, ethinylestradiol or norethindrone were observed after co-administration with rosiglitazone.
4.6 Pregnancy And Lactation
Pregnancy
Rosiglitazone has been reported to cross the human placenta and to be detectable in the foetal tissues. There are no adequate data from the use of rosiglitazone in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3). The potential risk for humans is unknown. Rosiglitazone should not be used during pregnancy.
Breast-feeding
Rosiglitazone has been detected in the milk of experimental animals. It is not known whether breast-feeding will lead to exposure of the infant to drug. Rosiglitazone should therefore not be used in women who are breast-feeding.
Fertility
As a consequence of improving insulin sensitivity, resumption of ovulation may occur in patients who are anovulatory due to insulin resistance (e.g. patients with polycystic ovary syndrome). Patients should be aware of the risk of pregnancy and if a patient wishes to become pregnant or if pregnancy occurs the treatment should be discontinued.
4.7 Effects On Ability To Drive And Use Machines
AVANDIA has no or negligible influence on the ability to drive and use machines.
4.8 Undesirable Effects
Clinical trial data
The most commonly reported adverse reactions during treatment with rosiglitazone are dose-dependent fluid-related reactions which include oedema and anaemia. Concurrent rosiglitazone and sulphonylurea therapy may be associated with an increased frequency of hypoglycaemia and anaemia compared to rosiglitazone monotherapy. It is important to monitor patients for fluid retention which may exacerbate or precipitate signs or symptoms of congestive heart failure (see section 4.4).
Adverse reactions for each treatment regimen are presented below by system organ class and absolute frequency. For dose-related adverse reactions the frequency category reflects the higher dose of rosiglitazone. Frequency categories do not account for other factors including varying study duration, pre-existing conditions and baseline patient characteristics. Adverse reaction frequency categories assigned based on clinical trial experience may not reflect the frequency of adverse reactions occurring during normal clinical practice. Frequencies are defined as: very common (
Table 1 lists adverse reactions identified from an overview of clinical trials involving over 5,000 rosiglitazone-treated patients. Within each system organ class, adverse reactions are presented in the table by decreasing frequency for the rosiglitazone monotherapy treatment regimen. Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Table 1. The frequency of adverse reactions identified from clinical trial data
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RSG - Rosiglitazone monotherapy; RSG + MET - Rosiglitazone with metformin; RSG + SU - Rosiglitazone with sulphonylurea; RSG + MET + SU - Rosiglitazone with metformin and sulphonylurea
*The frequency category for the background incidence of these adverse reactions, as taken from placebo group data from clinical trials, is 'common'.
1 Hypercholesterolaemia was reported in up to 5.3 % of patients treated with rosiglitazone (monotherapy, dual or triple oral therapy). The elevated total cholesterol levels were associated with increase in both LDLc and HDLc, but the ratio of total cholesterol: HDLc was unchanged or improved in long term studies. Overall, these increases were generally mild to moderate and usually did not require discontinuation of treatment.
2 An increased incidence of heart failure has been observed when rosiglitazone was added to treatment regimens with a sulphonylurea (either as dual or triple therapy), and appeared higher with 8 mg rosiglitazone compared to 4 mg rosiglitazone (total daily dose). The incidence of heart failure on triple oral therapy was 1.4 % in the main double blind study, compared to 0.4 % for metformin plus sulphonylurea dual therapy. The incidence of heart failure in combination with insulin (rosiglitazone added to established insulin therapy) was 2.4 %, compared to insulin alone, 1.1 %. Moreover in patients with congestive heart failure NYHA class I-II, a placebo-controlled one-year trial demonstrated worsening or possible worsening of heart failure in 6.4 % of patients treated with rosiglitazone, compared with 3.5 % on placebo.
3In a retrospective analysis of data from 42 pooled short-term clinical studies, the overall incidence of events typically associated with cardiac ischaemia was higher for rosiglitazone containing regimens, 2.00 % versus combined active and placebo comparators, 1.53 % [hazard ratio (HR) 1.30 (95 % confidence interval (CI) 1.004 - 1.69)]. This risk was increased when rosiglitazone was added to established insulin and in patients receiving nitrates for known ischaemic heart disease. In an update to this retrospective analysis that included 10 further studies that met the criteria for inclusion, but were not available at the time of the original analysis, the overall incidence of events typically associated with cardiac ischaemia was not statistically different for rosiglitazone containing regimens, 2.21 % versus combined active and placebo comparators, 2.08 % [HR 1.098 (95 % CI 0.809 - 1.354)]. In a prospective cardiovascular outcomes study (mean follow-up 5.5 years) the primary endpoint events of cardiovascular death or hospitalisation were similar between rosiglitazone and active comparators [HR 0.99 (95 % CI 0.85 - 1.16)]. Two other long-term prospective randomised controlled clinical trials (9,620 patients, study duration>3 years in each study), comparing rosiglitazone to some other approved oral antidiabetic medicinal products or placebo, have not confirmed or excluded the potential risk of cardiac ischaemia. In their entirety, the available data on the risk of cardiac ischaemia are inconclusive.
4 Long-term studies show an increased incidence of bone fracture in patients, particularly female patients, taking rosiglitazone. In a monotherapy study, the incidence in females for rosiglitazone was 9.3 % (2.7 patients per 100 patient years) vs 5.1 % (1.5 patients per 100 patient years) for metformin or 3.5 % (1.3 patients per 100 patient years) for glibenclamide. In another long-term study, there was an increased incidence of bone fracture for subjects in the combined rosiglitazone group compared to active control [8.3 % vs 5.3 %, Risk ratio 1.57 (95 % CI 1.26 - 1.97)]. The risk of fracture appeared to be higher in females relative to control [11.5 % vs 6.3 %, Risk ratio 1.82 (95 % CI 1.37 - 2.41)], than in males relative to control [5.3 % vs 4.3 %, Risk ratio 1.23 (95 % CI 0.85 - 1.77)]. Additional data are necessary to determine whether there is an increased risk of fracture in males after a longer period of follow-up. The majority of the fractures were reported in the upper limbs and distal lower limbs (see section 4.4).
In double-blind clinical trials with rosiglitazone the incidence of elevations of ALT greater than three times the upper limit of normal was equal to placebo (0.2 %) and less than that of the active comparators (0.5 % metformin/sulphonylureas). The incidence of all adverse reactions relating to liver and biliary systems was < 1.5 % in any treatment group and similar to placebo.
Post-marketing data
In addition to the adverse reactions identified from clinical trial data, the adverse reactions presented in Table 2 have been identified in post approval use of rosiglitazone. Frequencies are defined as: rare
Table 2. The frequency of adverse reactions identified from post-marketing data
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5 Rare cases of elevated liver enzymes and hepatocellular dysfunction have been reported. In very rare cases a fatal outcome has been reported.
4.9 Overdose
Limited data are available with regard to overdose in humans. In clinical studies in volunteers rosiglitazone has been administered at single oral doses of up to 20 mg and no serious adverse reactions were observed.
In the event of an overdose, it is recommended that appropriate supportive treatment should be initiated, as dictated by the patient's clinical status. Rosiglitazone is highly protein bound and is not cleared by haemodialysis.
5. Pharmacological Properties
5.1 Pharmacodynamic Properties
Pharmacotherapeutic group: Drugs used in diabetes, blood glucose lowering drugs, excluding insulins, ATC code: A10 BG 02
Rosiglitazone is a selective agonist at the PPARγ (peroxisomal proliferator activated receptor gamma) nuclear receptor and is a member of the thiazolidinedione class of anti-diabetic medicinal products. It reduces glycaemia by reducing insulin resistance at adipose tissue, skeletal muscle and liver.
Preclinical data
The antihyperglycaemic activity of rosiglitazone has been demonstrated in a number of animal models of type 2 diabetes. In addition, rosiglitazone preserved ß-cell function as shown by increased pancreatic islet mass and insulin content and prevented the development of overt hyperglycaemia in animal models of type 2 diabetes. Rosiglitazone did not stimulate pancreatic insulin secretion or induce hypoglycaemia in rats and mice. The major metabolite (para-hydroxy-sulphate) with high affinity to the soluble human PPARγ, exhibited relatively high potency in a glucose tolerance assay in obese mouse. The clinical relevance of this observation has not been fully elucidated.
Clinical trials data
The glucose lowering effects observed with rosiglitazone are gradual in onset with near maximal reductions in fasting plasma glucose (FPG) evident following approximately 8-weeks of therapy. The improved glycaemic control is associated with reductions in both fasting and post-prandial glucose.
Rosiglitazone was associated with increases in weight. In mechanistic studies, the weight increase was predominantly shown to be due to increased subcutaneous fat with decreased visceral and intra-hepatic fat.
Consistent with the mechanism of action, rosiglitazone reduced insulin resistance and improved pancreatic ß-cell function. Improved glycaemic control was also associated with significant decreases in free fatty acids. As a consequence of different but complementary mechanisms of action, dual oral therapy of rosiglitazone with a sulphonylurea or metformin resulted in additive effects on glycaemic control in type 2 diabetic patients.
In studies with a maximal duration of three years, rosiglitazone given once or twice daily produced a sustained improvement in glycaemic control (FPG and HbA1c). A more pronounced glucose-lowering effect was observed in obese patients. An outcome study has not been completed with rosiglitazone, therefore the long-term benefits associated with improved glycaemic control have not been demonstrated.
ADOPT (A Diabetes Outcome Progression Trial) was a multicentre, double-blind, controlled trial with a treatment duration of 4-6 years (median duration of 4 years), in which rosiglitazone at doses of 4 to 8 mg/day was compared to metformin (500 mg to 2000 mg/day) and glibenclamide (2.5 to 15 mg/day) in 4351 drug naive subjects recently diagnosed (
The RECORD (Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of glycaemia in Diabetes) trial was a large (4,447 subjects), open-label, prospective, controlled study (mean follow-up 5.5 years) in which patients with type 2 diabetes inadequately controlled with metformin or sulphonylurea were randomised to add-on rosiglitazone or metformin or sulphonylurea. The mean duration of diabetes in these patients was approximately 7 years. The adjudicated primary endpoint was cardiovascular hospitalisation (which included hospitalisations for heart failure) or cardiovascular death. Mean doses at the end of randomised treatment are shown in the following table:
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*Similar relative effective doses (i.e approximately half maximal dose) for other sulphonylureas (glibenclamide and glicazide).
† Patients who took designated treatment as randomised in combination with the correct background treatment and with evaluable data.
No difference in the number of adjudicated primary endpoint events for rosiglitazone (321/2220) versus active control (323/2227) (HR 0.99, CI 0.85-1.16) was observed, meeting the pre-defined non-inferiority criterion of 1.20 (non-inferiority p = 0.02). HR and CI for key secondary endpoints were: all-cause death (HR 0.86, CI 0.68-1.08), MACE (Major Adverse Cardiac Events - cardiovascular death, acute myocardial infarction, stroke) (HR 0.93, CI 0.74-1.15), cardiovascular death (HR 0.84, CI 0.59-1.18), acute myocardial infarction (HR 1.14, CI 0.80-1.63) and stroke (HR 0.72, CI 0.49-1.06). In a sub-study at 18 months, add-on rosiglitazone dual therapy was non-inferior to the combination of sulphonylurea plus metformin for lowering HbA1c. In the final analysis at 5 years, an adjusted mean reduction from baseline in HbA1c of 0.14 % for patients on rosiglitazone added to metformin versus an increase of 0.17 % for patients taking sulphonylurea added to metformin was seen during treatment with randomised dual-combination therapy (p<0.0001 for treatment difference). An adjusted mean reduction in HbA1c of 0.24 % was seen for patients taking rosiglitazone added to sulphonylurea, versus a reduction in HbA1c of 0.10 % for patients taking metformin added to sulphonylurea, (p=0.0083 for treatment difference). There was a significant increase in heart failure (fatal and non-fatal) (HR 2.10, CI 1.35-3.27) and bone fractures (Risk Ratio 1.57, CI 1.26-1.97) in rosiglitazone-containing treatments compared to active control (see sections 4.4 and 4.8). A total of 564 patients withdrew from cardiovascular follow-up, which accounted for 12.3 % of rosiglitazone patients and 13 % of control patients; representing 7.2 % of patient-years lost for cardiovascular events follow-up and 2.0 % of patient-years lost for all cause mortality follow-up.
Paediatric population
An active controlled clinical trial (rosiglitazone up to 8 mg daily or metformin up to 2,000 mg daily) of 24 weeks duration was performed in 197 children and adolescents (10-17 years of age) with type 2 diabetes. Improvement in HbA1c from baseline achieved statistical significance only in the metformin group. Rosiglitazone failed to demonstrate non-inferiority to metformin. Following rosiglitazone treatment, there were no new safety concerns noted in children and adolescents compared to adult patients with type 2 diabetes mellitus. No long-term efficacy and safety data are available in paediatric patients.
The European Medicines Agency has waived the obligation to submit the results of studies with AVANDIA in all subsets of the paediatric population in Type II diabetes mellitus (see section 4.2 for information on paediatric use).
5.2 Pharmacokinetic Properties
Absorption
Absolute bioavailability of rosiglitazone following both a 4 and an 8 mg oral dose is approximately 99 %. Rosiglitazone plasma concentrations peak at around 1 hour after dosing. Plasma concentrations are approximately dose proportional over the therapeutic dose range.
Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), although a small decrease in Cmax (approximately 20 % to 28 %) and a delay in tmax (ca.1.75 h) were observed compared to dosing in the fasting state. These small changes are not clinically significant and, therefore, it is not necessary to administer rosiglitazone at any particular time in relation to meals. The absorption of rosiglitazone is not affected by increases in gastric pH.
Distribution
The volume of distribution of rosiglitazone is approximately 14 litres in healthy volunteers. Plasma protein binding of rosiglitazone is high (approximately 99.8 %) and is not influenced by concentration or age. The protein binding of the major metabolite (para-hydroxy-sulphate) is very high (>99.99 %).
Biotransformation
Metabolism of rosiglitazone is extensive with no parent compound being excreted unchanged. The major routes of metabolism are N-demethylation and hydroxylation, followed by conjugation with sulphate and glucuronic acid. The contribution of the major metabolite (para-hydroxy-sulphate) to the overall anti-diabetic activity of rosiglitazone has not been fully elucidated in man and it cannot be ruled out that the metabolite may contribute to the activity. However, this raises no safety concern regarding target or special populations as hepatic impairment is contraindicated and the phase III clinical studies included a considerable number of elderly patients and patients with mild to moderate renal impairment.
In vitro studies demonstrate that rosiglitazone is predominantly metabolised by CYP2C8, with a minor contribution by CYP2C9.
Since
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